课程文献中心 更多>>

关键词： 肝细胞癌   免疫治疗   肿瘤疫苗  

关键词： 泌酸腺肿瘤   胃底腺型腺癌   泌酸腺腺瘤   表达解痉多肽的化生   TFF2  

关键词： BNIP3   消化道肿瘤   凋亡   自噬   治疗靶点  

关键词： Choroid neoplasms   Fluorescein angiography   Melanoma   Nevus   optical coherence   pigmented   Tomography  

摘要： Objective To describe and compare the internal vascular features of choroidal melanoma (CM) and choroidal nevus on optical coherence tomography angiography (OCTA). Methods This cross-sectional study included patients clinically diagnosed with CM or choroidal nevus at Beijing Tongren Hospital between July 2019 and March 2025. Tumor-centered OCTA images were acquired, and the intrinsic tumor vasculature was reconstructed on two en face planes, the choriocapillaris slab and the full-thickness choroid slab. The malignant transformation risk of choroidal nevus was assessed using the multimodal imaging-based TFSOM-DIM criteria. Nevi with two or more high-risk features were classified as high-risk nevi, and the OCTA features of high and low-risk nevi was analyzed. The OCTA features were compared between the CM and nevus groups using the χ² test or Fisher′s exact test. Results A total of 95 eyes (95 patients) were included, consisting of 49 right eyes and 46 left eyes. There were 45 males (47.4%) and 50 females (52.6%), with a mean age of (47.6±14.1) years. All patients had unilateral involvement. The CM group included 67 patients (67 eyes), with 35 right eyes and 32 left eyes, comprising 36 males (53.7%) and 31 females (46.3%), with a mean age of (47.1±14.3) years. The choroidal nevus group included 28 patients (28 eyes), with 14 right eyes and 14 left eyes, consisting of 9 males (32.1%) and 19 females (67.9%), with a mean age of 48.8±13.6 years. There were no significant differences between the two groups in eye laterality (χ²=0.04, P=0.842), age (t=0.53, P=0.299), or sex distribution (χ²=3.69, P=0.055). In the choroid en face slab, disorganized vascular networks and vascular loops were observed in 66 CM cases (98.5%) and 14 nevus cases (50.0%;χ²=34.95, P<0.001). In the choriocapillaris en face slab, patchy avascular areas were detected in 54 CM cases (80.6%) and 9 nevi (32.1%;χ²=20.79, P<0.001), while the intrinsic tumor vasculature was present in 52 CM cases (77.6%) and

关键词： 嵌合抗原受体T细胞   免疫治疗   肿瘤治疗   文献计量学   可视化分析  

关键词： 肿瘤   Src   Src激酶抑制剂   纳米颗粒  

关键词： 青少年多形性低级别神经上皮肿瘤   磁共振成像   癫痫  

摘要： 1病例资料患者男，12岁，无明显诱因癫痫发作1年余，发作时无意识。外院磁共振成像（magnetic resonance imaging,MRI）检查提示左侧海马区轻度强化灶，初步考虑为低级别胶质瘤。患者为求进一步治疗来南京医科大学第一附属医院就诊。病程中患者精神尚可，无恶心、呕吐，无头晕、黑矇，饮食睡眠状况尚可。患者有青霉素类抗生素过敏史，无慢性病史，无传染病及其密切接触史，无家族遗传病史。

关键词： DNA methylation   Epilepsy   Glioma   Neoplasms, neuroepithelial   Sequence analysis, DNA  

摘要： Objective To investigate the clinical, radiologic, pathological and molecular genetic features of polymorphous low-grade neuroepithelial tumor of the young (PLNTY). Methods A retrospective analysis was performed on fourteen PLNTY cases, diagnosed at the Department of Pathology, Xuanwu Hospital, Capital Medical University, from August 2018 to December 2024. The clinical, radiologic, prognostic, histopathological, molecular genetic features, and DNA methylation clustering were analyzed. Results Among the 14 patients (10 males, 4 females), the age range was 8-34 years, with a median age of 21 (14, 29) years. The patient′s major, initial clinical symptom was epilepsy (13/14). Among 9 MRI exanimated cases, 4 showed cystic-solid abnormal signals, and 5 appeared as solid masses. Most were hypointense on T1 and hyperintense on T2. Five cases had enhancement, with no obvious diffusion restriction on DWI. Among 5 CT examined cases, 4 showed high density, and 1 showed low density. The characteristic histopathologic features of the tumor cells were oligodendroglioma-like, spindle, pleomorphic and associated with foci of calcifications. GFAP and Olig2 were expressed in tumor cells in all 14 cases (14/14). Neuronal markers (NeuN, NF) were negative in 13/13 cases. CD34 showed diffuse strong positivity in all cases (14/14). BRAF V600E was positive in 8/11 cases. Thirteen cases (13/13) harbored mitogen-activated protein kinase (MAPK) pathway alterations, including BRAF (10/13) and FGFR2/3 (3/13) gene mutations. In 7 PLNTY cases, t-SNE cluster analysis of DNA methylation profiles showed clustering with ganglioglioma, PLNTY, and pilocytic astrocytoma. Until November 2025, 13 patients have been seizure-free postoperatively, and all 14 patients showed no tumor progression or recurrence. Conclusions PLNTY usually occurs in adolescents and is associated with epilepsy. Its diagnosis necessitates a combination of clinical, histopathological, and molecular genetic alterations. In molecular l

关键词： 碳点   pH响应   溶酶体逃逸   阿霉素释放