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摘要： 研究老年恶性肿瘤患者的安宁疗护中,应用医联体、安心卡引导模式下尊严照护的效果,以及对其睡眠质量的影响。方法:本研究选取本院及外院120例老年恶性肿瘤患者作为观察对象,以上患者均在2021年1月至2022年12月期间收治。通过随机数字表法将患者分为两组:一组接受常规护理(作为对照组,n=60),另一组则采用医联体结合安心卡引导的尊严照护模式(作为观察组,n=60)。随后,本研究对比两组患者的护理效果。结果:于睡眠质量方面,观察组患者PSQI各维度分值和总分值均低于对照组,P<0.05;于生活质量方面,以观察组患者QLQ-C30各项评分值均更高,P<0.05。结论:在老年恶性肿瘤患者的安宁疗护中,通过医联体和安心卡引导的尊严照护护理,可获显著效果。

关键词： photoacoustic therapy   self-collapsing   physical ablation   chemical intervention   oxidative stress  

摘要： Circumventing the tumor's defensive antioxidant system and achieving precision cancer therapy are the major challenges in achieving high-efficacy tumor treatments. In this study, we propose a rational and effective therapeutic strategy by synergistically integrating the effects of a non-oxidative physical ablation and an oxidative chemical intervention. An acid-responsive self-collapsing nanomineral PCSB is constructed, which consists of a poly(acrylic acid) (PAA)-modified calcium sulfite (CaSO3) and a pH-responsive photoacoustic (PA) therapeutic molecule, aza-BDP. The tumor acidic microenvironment promotes the decomposition of PCSB, triggering the release of PA agents and SO2/Ca2+, thereby achieving the synergistic therapy of non-oxidative mechanical damage from PA therapeutic effect and oxidative chemical damage from SO2 gas and Ca2+ metal ion therapeutic effects. Therefore, this study presents a synergistic physical and chemical treatment strategy, which shows significant potential for reducing the resistance conferred by the antioxidant mechanisms of tumor cells and improving the precision of treatment.

关键词： 自噬   耐药性   消化道肿瘤  

关键词： 国家自然科学基金委员会   中药抗肿瘤药理   资助项目   研究方向  

关键词： DNA甲基化   肿瘤   DNA甲基转移酶   脱甲基酶   分子靶向治疗   抗肿瘤药   基因表达调控   表观遗传学  

关键词： Cancer treatment   Hematologic neoplasms   Hematopoietic stem cell transplantation   Neutropenia   Pegylated recombinant human granulocyte colony-stimulating factor  

摘要： Neutropenia is one of the most common hematologic toxicities during the treatment of hematologic malignancies. It can lead to delays in subsequent treatments, dose reduction of chemotherapeutic agents, or even treatment discontinuation. Furthermore, neutropenia increases the risk of febrile neutropenia and severe infections, which adversely affect patient prognosis. Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) is effective in preventing and treating neutropenia, and is widely used in the treatment of hematologic malignancies and hematopoietic stem cell transplantation (HSCT). To further promote the standardized application of PEG-rhG-CSF in hematological malignancies, the Hematology Oncology Committee of China Anti-Cancer Association organized domestic experts in the related fields, based on current evidence-based medical data and clinical practice, to focus on the clinical application of PEG-rhG-CSF in hematologic malignancies, hematopoietic stem cell mobilization and hematopoietic function reconstitution after HSCT. Eight recommendation opinions were finally proposed to guide the standardized use of drugs in clinical practice. 2026, Chinese Medical Association

关键词： miR-126   表达调控   恶性肿瘤   靶基因  

关键词： 肿瘤恶液质   代谢异常   系统性炎症   胃肠道损伤   中医药