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摘要： 研究老年恶性肿瘤患者的安宁疗护中,应用医联体、安心卡引导模式下尊严照护的效果,以及对其睡眠质量的影响。方法:本研究选取本院及外院120例老年恶性肿瘤患者作为观察对象,以上患者均在2021年1月至2022年12月期间收治。通过随机数字表法将患者分为两组:一组接受常规护理(作为对照组,n=60),另一组则采用医联体结合安心卡引导的尊严照护模式(作为观察组,n=60)。随后,本研究对比两组患者的护理效果。结果:于睡眠质量方面,观察组患者PSQI各维度分值和总分值均低于对照组,P<0.05;于生活质量方面,以观察组患者QLQ-C30各项评分值均更高,P<0.05。结论:在老年恶性肿瘤患者的安宁疗护中,通过医联体和安心卡引导的尊严照护护理,可获显著效果。

关键词： 肿瘤   低价值医疗   文献计量学   知识图谱  

关键词： miR-126   表达调控   恶性肿瘤   靶基因  

关键词： 肿瘤恶液质   代谢异常   系统性炎症   胃肠道损伤   中医药  

关键词： 高光谱   显微成像   光谱标定   病理分析  

关键词： 恶性肿瘤   神经毒性   健脾   标本同治   张晓春   名中医  

关键词： 通补兼施   恶性肿瘤   梗阻  

关键词： 免疫检查点抑制剂   联合治疗   肿瘤免疫治疗   耐药性   免疫相关不良事件  

关键词： bacteria   hypoxia targeting   surface modification   photothermal therapy   immunotherapy  

摘要： Cancer immunotherapy is an attractive strategy clinically, in which small molecule immune checkpoint inhibitors (ICIs) are widely used due to their low cost, short half-life, and high diffusion rate in tumor after oral administration. However, this monotherapy is accompanied by limited efficacy and undesirable systemic side effects. Herein, we proposed a simple and safe strategy to engineer bacteria for tumor-targeted and synergistic therapy. First, the photothermal nanoagent polydopamine (PDA) was coated on the surface of non-pathogenic Escherichia coli MG1655 through in situ polymerization, followed by the noncovalent attachment of an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor NLG919 to result in MG1655@PDA-NLG. The functionalized bacteria exhibited outstanding photothermal conversion properties with unaffected viability and bioactivity. In a murine subcutaneous CT26 colon tumor model, they effectively accumulated in the tumor within 12 h post intravenous injection and were completely cleared from the major organs by 72 h with negligible hematological toxicity, confirming the excellent hypoxic tumor-targeting ability and biosafety. Under near-infrared light irradiation, the engineered bacteria significantly inhibited tumor growth by over 90% on the basis of photothermal effect and induced immunogenic cell death (ICD) to promote dendritic cell (DC) maturation, which synergized with immunosuppression of tryptophan (Trp) metabolism for enhanced CD4(+) and CD8(+) T cell infiltration. This work would inspire the development of multifunctional bacteria through surface integration with multiple therapeutic agents for precise and combined cancer immunotherapy.

关键词： 肾脏精准手术   影像组学   大数据   人工智能   外科决策